Propranolol pharmacokinetics and pharmacodynamics after single doses and at steady-stateLALONDE, R. L; PIEPER, J. A; STRAKA, R. J et al.European journal of clinical pharmacology. 1987, Vol 33, Num 3, pp 315-318, issn 0031-6970Article

Drug Development Perspective on Pharmacokinetic Studies of New Drugs in Patients With Renal ImpairmentLALONDE, R. L; WAGNER, J. A.Clinical pharmacology and therapeutics. 2009, Vol 86, Num 5, pp 557-561, issn 0009-9236, 5 p.Article

Propranolol pharmacodynamic modeling using unbound and total concentrations in healthy volunteersLALONDE, R. L; STRAKA, R. J; PIEPER, J. A et al.Journal of pharmacokinetics and biopharmaceutics. 1987, Vol 15, Num 6, pp 569-582, issn 0090-466XArticle

Population pharmacokinetics of terfenadineLALONDE, R. L; LESSARD, D; GAUDREAULT, J et al.Pharmaceutical research. 1996, Vol 13, Num 6, pp 832-838, issn 0724-8741Article

Comparison of QTc Data Analysis Methods Recommended by the ICH E14Guidance and Exposure-Response Analysis: Case Study of a Thorough QT Study of AsenapineCHAPEL, S; HUTMACHER, M. M; BOCKBRADER, H et al.Clinical pharmacology and therapeutics. 2011, Vol 89, Num 1, pp 75-80, issn 0009-9236, 6 p.Article

The Use of a Clinical Utility Index to Compare Insomnia Compounds : A Quantitative Basis for Benefit-Risk AssessmentOUELLET, D; WERTH, J; PAREKH, N et al.Clinical pharmacology and therapeutics. 2009, Vol 85, Num 3, pp 277-282, issn 0009-9236, 6 p.Article

Labetalol pharmacokinetics and pharmacodynamics : evidence of stereoselective dispositionLALONDE, R. L; O'REAR, T. L; WAINER, I. W et al.Clinical pharmacology and therapeutics. 1990, Vol 48, Num 5, pp 509-519, issn 0009-9236, 11 p.Article

Comparison of high pressure liquid chromatography and fluorescence polarization immunoassay to assess quinidine pharmacokineticsBOTTORFF, M. B; LALONDE, R. L; STRAUGHN, A. B et al.Biopharmaceutics & drug disposition. 1987, Vol 8, Num 3, pp 212-221, issn 0142-2782Article

Nonlinear pharmacokinetics of unbound propranolol after oral administrationSTRAKA, R. J; LALONDE, R. L; PIEPER, J. A et al.Journal of pharmaceutical sciences. 1987, Vol 76, Num 7, pp 521-524, issn 0022-3549Article

Two- and four-day rifampin chemoprophylaxis regimens induced oxidative metabolismBORCHERDING, S. M; BASTIAN, T. L; SELF, T. H et al.Antimicrobial agents and chemotherapy. 1992, Vol 36, Num 7, pp 1553-1558, issn 0066-4804Article

Measurement of underivatized propranolol enantiomers in serum using a cellulose-tris(3,5-dimethylphenylcarbamate) high-performance liquid chromatographic (HPLC) chiral stationary phaseSTRAKA, R. J; LALONDE, R. L; WAINER, I. W et al.Pharmaceutical research. 1988, Vol 5, Num 3, pp 187-189, issn 0724-8741Article

Nonlinear accumulation of propanolol enantiomersLALONDE, R. L; BOTTORFF, M. B; STRAKA, R. J et al.British journal of clinical pharmacology. 1988, Vol 26, Num 1, pp 100-102, issn 0306-5251Article

The effect of histamine-2 receptor antagonists on tocaidine pharmacokineticsNORTH, D. S; MATTERN, A. L; KAPIL, R. P et al.Journal of clinical pharmacology. 1988, Vol 28, Num 7, pp 640-643, issn 0091-2700Article

Model-based drug developmentLALONDE, R. L; KOWALSKI, K. G; TENSFELDT, T. G et al.Clinical pharmacology and therapeutics. 2007, Vol 82, Num 1, pp 21-32, issn 0009-9236, 12 p.Article

Population pharmacokinetics of pemetrexed disodium (ALIMTA) in patients with cancerOUELLET, D; PERICLOU, A. P; JOHNSON, R. D et al.Cancer chemotherapy and pharmacology. 2000, Vol 46, Num 3, pp 227-234, issn 0344-5704Article

Comparison of different methods to evaluate population dose-response and relative potency : Importance of interoccasion variabilityLALONDE, R. L; OUELLET, D; KIMANANI, E. K et al.Journal of pharmacokinetics and biopharmaceutics. 1999, Vol 27, Num 1, pp 67-83, issn 0090-466XArticle

Clinical comparability of albuterol delivered by the breath-actuated inhaler (Spiros®) and albuterol by MDI in patients with asthmaGEOFFROY, P; LALONDE, R. L; AHRENS, R et al.Annals of allergy, asthma, & immunology. 1999, Vol 82, Num 4, pp 377-382, issn 1081-1206Article

A single-blind, crossover comparison of the pharmacokinetics and cognitive effects of a new diazepam rectal gel with intravenous diazepamCLOYD, J. C; LALONDE, R. L; BENIAK, T. E et al.Epilepsia (Copenhagen). 1998, Vol 39, Num 5, pp 520-526, issn 0013-9580Article

Truncated area under the curve as a measure of relative extent of bioavailability : Evaluation using experimental data and Monte Carlo simulationsGAUDREAULT, J; POTVIN, D; LAVIGNE, J et al.Pharmaceutical research. 1998, Vol 15, Num 10, pp 1621-1629, issn 0724-8741Article

Effects of age on the protein binding and disposition of propranolol stereoisomersLALONDE, R. L; TENERO, D. M; BURLEW, B. S et al.Clinical pharmacology and therapeutics. 1990, Vol 47, Num 4, pp 447-455, issn 0009-9236Article

Altered β-adrenergic sensitivity and protein 1-propranolol in the elderlyTENERO, D. M; BOTTORFF, M. B; BURLEW, B. S et al.Journal of cardiovascular pharmacology. 1990, Vol 16, Num 5, pp 702-707, issn 0160-2446, 6 p.Article

Calcium channel blockers as inhibitors of drug metabolismHUNT, B. A; SELF, T. H; LALONDE, R. L et al.Chest. 1989, Vol 96, Num 2, pp 393-399, issn 0012-3692Article

Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug DevelopmentMILLIGAN, P. A; BROWN, M. J; KRISHNASWAMI, S et al.Clinical pharmacology and therapeutics. 2013, Vol 93, Num 6, pp 502-514, issn 0009-9236, 13 p.Article

Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568LALONDE, R. L; GAUDREAULT, J; KARHU, D. A et al.Clinical pharmacology and therapeutics. 1999, Vol 65, Num 1, pp 40-49, issn 0009-9236Article

Solid-phase extraction and direct high-performance liquid chromatographic determination of metoprolol enantiomers in plasmaHERRING, V. L; BASTIAN, T. L; LALONDE, R. L et al.Journal of chromatography. Biomedical applications. 1991, Vol 567, Num 1, pp 221-227, issn 0378-4347Article